Epithelial and Neural Localization and Heparin Binding of the Cell-Substratum Adhesion Molecule, Epinectin
نویسندگان
چکیده
منابع مشابه
Topographic localization of the heparin-binding domain of the neural cell adhesion molecule N-CAM
Previous studies have reported that the cell-binding region of the neural cell adhesion molecule (N-CAM) resides in a 65,000-D amino-terminal fragment designated Frl (Cunningham, B. A., S. Hoffman, U. Rutishauser, J. J. Hemperly, and G. M. Edelman, 1983, Proc. Natl. Acad. Sci. USA, 80:3116-3120). We have reported the presence of two functional domains in N-CAM, each identified by a specific mAb...
متن کاملA heparin-binding domain from N-CAM is involved in neural cell- substratum adhesion
Cell-substratum adhesion in the embryonic chicken nervous system has been shown to be mediated in part by a 170,000-mol-wt polypeptide that is a component of adherons. Attachment of retinal cells to the 170,000-mol-wt protein is inhibited by the C1H3 monoclonal antibody and by heparan sulfate (Cole, G. J., D. Schubert, and L. Glaser, 1985, J. Cell Biol., 100:1192-1199). In the present study we ...
متن کاملStructural requirements for neural cell adhesion molecule-heparin interaction.
Two biological domains have been identified in the amino terminal region of the neural cell adhesion molecule (NCAM): a homophilic-binding domain, responsible for NCAM-NCAM interactions, and a heparin-binding domain (HBD). It is not known whether these two domains exist as distinct structural entities in the NCAM molecule. To approach this question, we have further defined the relationship betw...
متن کاملBinding properties of a cell adhesion molecule from neural tissue.
We have previously identified and purified a cell surface glycoprotein from retina and brain, called neural cell adhesion molecule or N-CAM, that appears to be involved in neural cell--cell adhesion, the fasciculation of neurites, and the formation of normal tissue patterns in the retina. The present studies reveal that artificial vesicles containing lipid and purified N-CAM bind to different c...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1988
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12463285